Selected Publications (from 2002)

 

Porter AE, Hobbs LW, Benezra Rosen V, and Spector M.  The ultrastructure of the plasma-sprayed hydroxyapatite-bone interface predisposing to bone bonding.  Biomat. 2002;23:725-733.

Grottkau BE, Noordin S, Shortkroff S, Schaffer JL, Thornhill TS, and Spector M.  Effect of mechanical perturbation on the release of PGE2 by macrophages in vitro.  J. Biomed. Mater. Res. 2002;59:288-293.

Brock DP, Marty-Roix R, and Spector M.  a-smooth muscle actin in and contraction of porcine dental pulp cells. J. Dent. Res. 2002;81:203-208.

Kinner B and Spector M. Expression of smooth muscle actin in osteoblasts in human bone.  J. Orthop. Res. 2002;20:622-632.

Xiang Z and Spector M. A glimpse of tissue engineering in China. Tiss. Engr. 2002;8:169-174.

Kinner B, Gerstenfeld LC, Einhorn TA, and Spector M.  Expression of smooth muscle actin in connective tissue cells participating in fracture healing in a murine model.  Bone 2002;30:738-745.

Samuel RE, Lee CR, Ghivizzani S, Evans CH, Yannas IV, Olsen BR, and Spector M. Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices.  Human Gene Therapy 2002;13:791-802.

Spector M. Novel cell scaffold interactions encountered in tissue engineering: Contractile behavior of musculoskeletal connective tissue cells. Tiss. Engr. 2002;18:351-357.

Kinner B, Zaleskas JM, and Spector M.  Regulation of smooth muscle actin expression and contraction of adult human mesenchymal stem cells.  Exp. Cell Res. 2002;278:72-83.

Meaney Murray M, Bennett R, Zhang X, and Spector M.  Cell outgrowth from the human ACL in vitro: Regional variation and response to TGF-b1. J. Orthop. Res. 2002;20:875-880.

Lin BY, Richmond J, and Spector M.  Contractile actin expression in torn human menisci. Wound Rep. Regen. 2002;10:259-266.

 

Mazzucco D, McKinley G, Scott RD, and Spector M.  Rheology of joint fluid in total knee arthroplasty patients.  J. Orthop. Res. 2002;20:1157-1163.

Rong Y, Sugumaran G, Silbert JE, and Spector M.  Proteoglycans synthesized by canine intervertebral disc cells grown in a type I collagen–glycosaminoglycan matrix. Tiss. Engr. 2002;8:1037-1047.

Palmer G, Pascher A, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC. Development of gene-based therapies for cartilage repair  Crit. Rev. Eukaryot. Gene Expr. 2002;12:257-273.

Kinner B, Pacicca DM, Gerstenfeld LC, Lee C, Einhorn TA, and Spector M.  Expression of smooth muscle actin in cells involved in distraction osteogenesis in a rat model.  J. Orthop. Res. 2003;21:20-27.

Meaney Murray M, Rice K, Wright RJ, and Spector, M.  The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold.  J. Orthop. Res. 2003;21:238-244.

Lee CR, Grodzinsky AJ, Hsu H-P, and Spector M.  Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model.  J. Orthop. Res. 2003;21:272-281.

Lee CR, Grodzinsky AJ, and Spector M.  Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression.  J. Biomed. Mater. Res. 2003;64A:560-569.

Marty-Roix R, Bartlett JD, and Spector M. Growth of porcine enamel-, dentin-, and cementum-derived cells in collagen-GAG matrices in vitro: Expression of a-smooth muscle actin and contraction. Tiss. Engr. 2003;9:175-186.

Lee CR, Grodzinsky AJ, and Spector M. Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-GAG matrices.  Tiss. Engr. 2003;9:27-36.

Hindman HB, Marty-Roix R, Tang J-B, Jupiter J, Simmons B, and Spector M. Regulation of a-smooth muscle actin expression in cells of Dupuytren’s contracture.  J. Bone Jt. Surg. - Brit. Ed. 2003;85-B:448-455.

Mazzucco D and Spector M.  Effects of contact area and stress on the volumetric wear of ultrahigh molecular weight polyethylene.  Wear 2003;254:514-522.

Pek YS, Spector MS, Yannas IV, and Gibson LJ. Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and chondroitinase.  Biomat. 2004;25:473-482.

Capito RM and Spector M. Scaffold-based articular cartilage repair: Future prospects wedding gene therapy and tissue engineering.  IEEE Eng. Med. Biol. 2003;22:42-50.

Pascher A, Palmer GD, Oligino T, Gouze E, Gouze J-N, Spector M, Robbins PD, Evans CH, and Ghivizzani SC.  Gene delivery to cartilage defects using coagulated bone marrow aspirate.  Gene Therapy 2004;11:133-141.

Zaleskas JM, Kinner B,. Freyman TM, Yannas IV, Gibson LJ, and Spector M.  Contractile Forces Generated by Articular Chondrocytes in Collagen-Glycosaminoglycan Matrices.  Biomat. 2004;25:1299-1308.

Veilleux NH, Yannas IV, and Spector M.  Effect of passage number and collagen type on the proliferative, biosynthetic, and contractile activity of adult canine articular chondrocytes in type I and II collagen-glycosaminoglycan matrices in vitro.  Tiss. Engr. 2004;10:119-127.

Harley BA, Spilker MH, Wu JW, Asano K, Hsu H-P, Spector M, and Yannas IV. Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps. Cell Tiss. Org. 2004;176:153-165.

Mazzucco D, Scott R, and Spector M. ,Composition of joint fluid in Patients Undergoing total knee replacement and Revision arthroplasty: Correlation with Flow Properties.  Biomat. 2004;25:4433-4445.

Gordon TD, Schloesser L, Humphries DE, and Spector M.  Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro.  Tiss. Engr. 2004;10:1287-1295.

Vickers SM, Johnson LL, Zou LQ, Yannas IV, Gibson LJ, and Spector M.  Expression of a-smooth muscle actin in and contraction of cells derived from synovium.  Tiss. Engr. 2004;10: 1214-1223.

Hastreiter D, Chao J, Wang Q, Ozuna RM, and Spector M.  α-Smooth muscle actin in pathological human disc nucleus pulposus cells in vivo and in vitro.  Wound Rep. Regen. 2004;12:430-438.

Noordin S, Shortkroff S, Sledge CB, and Spector M.  Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates.  Biomat. 2004;25:5347-5352.

Porter AE, Hobbs LW, Blunn GW, Coathup MJ, and Spector M.  Bone-bonding to hydroxyapatite and titanium surfaces on human femoral stems retrieved at autopsy.  Biomat. 2004;25:5199-5208.

Saad L and Spector M. Effects of Collagen Type on the Behavior of Adult Canine Annulus Fibrosus Cells in Collagen-Glycosaminoglycan Scaffolds.  J. Biomed. Mater. Res. Part A 2004;71A:233-241.

Mazzucco D and Spector M. The role of joint fluid in the tribology of total joint arthroplasty.  Clin. Orthop. Rel. Res. 2004;429:17-32.

Frank E, Evans R, Lee C, Treppo S, Spector M, and Grodzinsky A. Quantitative electrical impedance analysis of cartilage degradation.  Biorheology 2004;41:195-202.

Wang H, Gerbaudo VH, Hobbs LW, and Spector M. Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6AI-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro.  Bone  2005;36:84-92.

Russlies M, Behrens P, Ehlers E-M,, Bröhl C, Spector M, and Kurz B. Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep model.  Cell and Tissue  2005;319:133-142.

Kinner B, Capito R.M., and Spector M.  Regeneration of Articular Cartilage.  Adv. Biochem. Engin./Biotechnol.  2005;94:91-123.

Tian WM, Hou SP, Ma J, Zhang CL, Xu QY, Lee IS, Li HD, Spector M, and Cui FZ, Hyaluronic acid–poly-D-lysine based three-dimensional hydrogel for traumatic brain injury.  Tiss. Engr.  2005;11:513-525.

Veilleux N and Spector M. Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in Type II collagen-glycosaminoglycan scaffolds In Vitro.Osteoart. and Cart. 2005;13:278-286.

Chen P, Marsilio E, Goldstein RH, Yannas IV, and Spector M.  Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitro.  Tiss. Engr. 2005;11:1436-1448.

Wang H, Eliaz N, Hsu H-P, Spector M, and Hobbs LW.  Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy.  Biomat. 2006;27:4192-4203.

Spector M.  Biomaterials-based tissue engineering and regenerative medicine. Solutions to musculoskeletal problems.  Swiss Medical Weekly 2006;136:293–301.

Vickers SM, Squitieri LS, and Spector M.  The effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: Dynamic pore reduction promotes cartilage formation.  Tiss. Engr. 2006;12:1345-55.

Sun W, Yan, Y, Lin, F, and Spector M.  Biomanufacturing: A US-China National Science Foundation-Sponsored Workshop.  Tiss. Engr. 2006;12:1169-1181.

Mazzucco, D and Spector, M.  Contact area as a critical determinant in the tribology of metal-on-polyethylene total joint arthroplasty.  J. Tribology  2006;128:113-121.

Hsu H-P, Zanella JM, Peckham SM, and Spector M.  Comparing ectopic bone growth induced by rhBMP-2 on an absorbable collagen sponge in rat and rabbit models.  J. Orthop. Res.  2006;24:1660-1669.

Xiang Z, Liao R, Kelly MS, and Spector M.  Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: A delivery vehicle for mesenchymal stem cells.  Tiss. Engr. 2006;12:2467-2478.

Cui F-Z, Lee I-S, and  Spector M.  Editorial: Welcome to Biomedical Materials. Biomed. Mater. 2006;1:1.

Capito R and Spector M.  Effect of expansion medium on ex vivo gene transfer and chondrogenesis in type II collagen-glycosaminoglycan scaffolds in vitro.  OsteoArthritis and Cart. 2006;14:1203-1213.

Capito R and Spector M. Collagen scaffolds for nonviral IGF-1 gene delivery in articular cartilage tissue engineering. Gene Therapy 2007;14:721-732.

Zhang D, Johnson LJ, Hsu H-P, and Spector M. Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: A histomorphometric study of PRG4 distribution in OA cartilage. J. Orthop. Res. 2007;25:873-883.

Tang S and  Spector M.  Incorporation of hyaluronic acid into collagen scaffolds for the control of chondrocyte-mediated contraction and chondrogenesis. Biomed. Mater. 2007;2:S135-S141.

Steinert A, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, and Evans CH.  Genetically enhanced engineering of meniscus tissue by ex vivo delivery of a TGF-β1 cDNA. Tiss. Engr. 2007;13:2227-2237.

Tang S, Vickers SM, Hsu H-P, and Spector M. Fabrication and characterization of porous hyaluronic acid-collagen composite scaffolds. J. Biomed. Mater. Res. 2007;82:323-335.

Xu X, Capito RM, and Spector M. ,Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles. J. Biomed. Mater. Res. (In press).

Xu X, Capito RM, and Spector M. , Plasmid size determines chitosan nanoparticle mediated gene transfer to chondrocytes. J. Biomed. Mater. Res. (In press).

Madaghiele M, Sannino A, Yannas I.V. and Spector M.  Collagen-based matrices with axially oriented pores. J. Biomed. Mater. Res. (In press).

 

 

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